DiMeN Doctoral Training Partnership

Determining mechanisms of glial cell interaction
during neurodegenerative disease in vivo

Application deadline: 6 January 2017

Candidates with a first or upper second class honors degree, or significant research experience in a biological discipline, are invited to apply for this 3.5-year funded PhD project under the auspices of the University of Sheffield and MRC DiMeN Doctoral Training Partnership. A desired criterion is some familiarity with quantitative and/or computational approaches.

This project will use in vivo time-lapse imaging of zebrafish retina development to uncover previously unknown mechanisms of glial cell interactions (MG and microglia) in the nervous system. The PhD candidate will also receive expert training in zebrafish transgenesis, genome editing and mutagenesis, molecular biology, cell labelling assays (e.g. in situ hybridisations, Immunohistochemistry) and computational morphometric analysis. This project should be of particular interest to highly motivated students who wish to cultivate interdisciplinary research skills, who have a keen interest in dissecting the link between cellular interactions during development, and who have an overarching interest in translational research and the genetic basis of neurodegenerative diseases.

Further information and documentation

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